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BEGIN:VEVENT
DTSTAMP:20240329T101532Z
UID:https://www.bi.mpg.de/events/14919/2855
DTSTART:20181108T120000Z
DTEND:20181108T130000Z
CLASS:PUBLIC
CREATED:20180806T122320Z
DESCRIPTION: Studies using the chicken have made very significant contribut
ions to understanding the development of vertebrates owing to the ease in
manipulating the chicken embryo. The chick model system has become even mo
re useful with the sequencing of the chicken genome and development of a r
obust method for transgenesis in the chicken (McGrew et al.\, 2004). It wa
s also shown that migratory primordial germ cells from the chicken could b
e cultured in vitro for extended periods and used to generate transgenic c
hickens (van de Lavoir et al\, 2006). My laboratory works on a type of ste
m cell in birds\, the primordial germ cell\, which is lineage restricted t
o producing spermatozoa and eggs of birds. These cells can be used to gene
rate gene edited chickens\, chicken which contain precise genetic changes
in their genome. We have previously demonstrated that chicken primordial g
erm cells can be efficiently modified in vitro using transposable e
lements. I will discuss our use of new CRISPR/Cas9 vector to efficient edi
t single nucleotides in primordial germ cells and the use of sterile surro
gate chicken hosts to increase germline transmission rates and decrease th
e time needed for production of genome edited chicken. A benefit of this r
esearch will be the technology to create bio-banks (frozen aviary) using g
erm cells. This is needed as the traditional methods used for species cryo
preservation using semen and eggs are either inefficient or impossible in
birds. Avian bio-banks will aid in the efforts to both manage and conserve
both rare and industrial breeds of poultry. The future challenge is to ex
tend biobanking to endangered bird species.\nVortragende(r): Dr. Mike McGr
ew
LAST-MODIFIED:20181019T130037Z
LOCATION:Seewiesen\, Raum: Seminar Room House 4\, Tea & Coffee 12:30h
ORGANIZER:Prof. Dr. Manfred Gahr
SUMMARY:Talk Mike McGrew\, Seewiesen: Mike McGrew\, University of Edinbu
rgh: Precision breeding and reproductive technologies for bird conserv
ation and tropical poultry adaptation
URL:https://www.bi.mpg.de/events/14919/2855
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