Talk Dr. Alexander Suh

Talk Alexander Suh, Seewiesen

11068 1505389153

A genomics perspective on selfish chromosomes of birds

  • Datum: 21.09.2017
  • Uhrzeit: 13:00 - 14:00
  • Vortragender: Dr. Alexander Suh
  • Uppsala University
  • Ort: Seewiesen
  • Raum: Seminar Room House 4, Tea & Coffee 12:30h
  • Gastgeber: Prof. Dr. Bart Kempenaers
  • Kontakt:
Most bird species have a diploid genome comprising around 80 chromosomes. Nearly all of these are relatively repeat-poor and gene-rich, and have been largely accessible with short-read sequencing technologies. There are, however, some chromosomes in the avian karyotype with considerable accumulation of selfish genetic elements such as transposable elements and endogenous viruses, which may imply that these chromosomes are in genetic conflict with the rest of the genome. Here I discuss ongoing research in our group focusing on two likely selfish chromosomes, the female-specific W chromosome in birds-of-paradise and the germline-specific chromosome in zebra finches. A combination of single-molecule technologies (such as long-read and linked-read sequencing) made it possible to access large parts of these highly repetitive chromosomes, showing that the birds-of-paradise W chromosome is highly enriched in endogenous retroviruses and the zebra finch germline-specific chromosome is highly enriched in tandemly repeated genes. These results raise the question of how much of the total genetic variation has previously been missed in avian genomics studies.
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